Aging

ALS

• Small proteins
• Acidic
• Heat stable
• Amphipathic
• Long half-life
• Phosphoprotein
• abundant neuronal proteins
• point mutations generate familial autosomic dominant diseases
• entire molecule assembles into filaments
• involved in numerous diseases
• neuronal and glial inclusions
• thread pathology and inclusions
• sequester chaperones, NF,...
• ubiquitinated, nitrated
•  associated in the same lesion sometimes
• synuclein can help tau to aggregated, and vice versa