1  M

2  D

3  V

4  F

5  M

6  K

7  G

8  L

9  S

10  K

11   AKEGVVAAAE

21  KTKQGVAEA

30 A -> Pro (familial mutation)

31  G

32 KTKEGV    lipid binding motif

38  L

39  Y possible nitration

40  V

41  GSKTKEGV

49 V

50  H

51  G

52  V

53 A -> Thr  (familial mutation)

TVAEKTK

61  EQVTNVGGAV

71  V  71-82: region responsible for aggregation

72 TGVTAVAQK

81  T

82  V

83  EGAGSIAA

91  ATGFVKKDQL

101 GKNEEGAPQE

111  GILEDMPVDP

121  DNEA

125  Y phosphorylation site (Tyr kinases of the src/Fyn family) ; possible nitration

126 EMP

129 S phosphorylated in aggregates

130 E

131 E

132  G

133  Y possible nitration

134  QDYEPE

140 A