Tau isoforms control microtubule stability

1. Microtubules are filaments of the cytoskeleton

2. Microtubules transport the synthetized materials from the cell body towards nerve endings.

3. Microtubules are consituted of polymerized tubulin dimers.

4. Microtubules are labile sutructures, stabilized by microtubule-associated protein tau.

5. Exon 10 tau isoforms (4R)  bind with more affinity to tubulin dimers, and increase microtubule stability.

6. Therefore, 4R tau are able to render the microtubules stiffer, longer

7. and enable to modify the morphology of neurites, as well as to control neuronal plasticity

8. Tau-tubulin intereaction is also regulated by the phosphorylation state of tau......NEXT