THE PROGRESSION OF TAU PATHOLOGY IN SPORADIC AND FAMILIAL ALZHEIMER'S DISEASE
Synergy of tauopathy and APP dysmetabolism
in familial and sporadic Alzheimer’s disease
Tauopathy is a degenerating process that
occurs frequently in ageing, and that is systematically
present in the entorhinal cortex of humans aged over
75 years. This cartoon represents our hypothesis
on the synergetic effect
of APP dysfunction, revealed by Ab aggregation, on
the neuron to neuron propagation of tau pathology. In
familial autosomal dominant Alzheimer’s disease
(FAD AD), the important APP burden generated by mutations
on APP or PS1 genes will boost tauopathy, after its
installation in the entorhinal region. In sporadic
AD, the APP burden is less important, and the spreading
of tauopathy is slower.
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