Tau phosphorylation
 

Phosphorylation sites on native tau proteins are indicated

Antibodies that recognize phosphorylation sites on tau are represented

Some kinases involved in tau phosphorylation have been characterized.

Antibodies that detect pathological sites are represented in white circles (ex: AT100, PHF-27, AP422).

PHF-tau are abnormally phosphorylated. They are pathological. They are more phosphorylated than native tau from biopsies (Sergeant, N., et al., Isoelectric point differentiates PHF-tau from biopsy-derived human brain tau proteins. Neuroreport, 1995. 6(16): p. 2217-20.)
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