Tau gene
This cartoon describes the production of the 6 tau isoforms found in the adult brain tissue from humans.
- Tau gene is located on chromosome 17.
- In the central nervous system, six different mRNA of tau are produced by alternative splicing.
- Then six different Tau proteins, six "isoforms" are produced
- Tau proteins are different in that they have or not the peptidic regions translated from exons 2, 3 and 10.
- There are 3 isoforms with the peptidic region of exon 10 (10+)
- There are 3 isoforms without the peptidic region of exon 10 (10-)
- The peptidic region of exon 10 corresponds to a forth repeated region (R), that interacts with tubulin dimers, the basic components of microtubules. There are 3 isoforms 3R and 3 isoforms 4R.
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