Biochemical staging of tau pathology

At stage 10 all cortical brain areas, as well as many subcortical areas, are affected by tau pathology. The patient is always severely demented.

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease. Delacourte et al. Neurology. 1999 Apr 12;52(6):1158-65.

1. Stage 0
2. Stage1
3. Stage 2
4. Stage 3
5. Stage 4
6. Stage 5
7. Stage 6
8. Stage 7
9. Stage 8
10. Stage 9
11. Stage 10

Having understood the pathway of tauopathy in the human brain affected by Alzheimer's disease, the main question is to know what is the fuel of tauopathy in AD, as well as in other tauopathies.

For AD, following the amyloid cascade hypothesis (ACH), we expect to see huge amounts of amyloid in the brain of patient decades or years before the first tau aggregates.

For the "believers" of ACH or the bAPPtists, we recommend not to see what is happening in the human brain, and to continue to believe in the mouse brain, peacefully.