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Risk factors of Alzheimer's disease

 

 

Risk factors

  1. APP pathology

  2. Tau pathology

  3. Age

  4. Genetic factors other than APP/PS1: ApoE, others

  5. Environmental factors:

    1. stress (cortisol)
    2. traumatisms
    3. associated pathologies (high blood pression)
    4. nutrition (cholesterol,...)
    5. homocystein
    6. diabetis
    7. metals
    8. ......

 

NEUROPROTECTANTS:

  1. neuronal plasticity,

  2. neuronal reservoir,

  3. constitutive vulnerability of hippocampus

  4. protective genetic factors : apoE2, ...

  5. environnemental factors (nutrition, absence of stress, good vascular system, low production of free radicals, etc)

 

 

 

Age

Apolipoprotein E

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