Risk factors of Alzheimer's disease

 

Risk factors

1. APP pathology

2. Tau pathology

3. Age

4. Genetic factors other than APP/PS1: ApoE, others

5. Environmental factors:

   1. stress (cortisol)
   2. traumatisms
   3. associated pathologies (high blood pression)
   4. nutrition (cholesterol,...)
   5. homocystein
   6. diabetis
   7. metals
   8. ......

NEUROPROTECTANTS:

1. neuronal plasticity,

2. neuronal reservoir,

3. constitutive vulnerability of hippocampus

4. protective genetic factors : apoE2, ...

5. environnemental factors (nutrition, absence of stress, good vascular system, low production of free radicals, etc)

Age

Apolipoprotein E