| A | L | Z | H | E | I | M | E | R | |
| 0-59years | 60-69years | 70-79years | >80 years | ||||||
| E2E2 | 0 | E2E2 | 1 | E2E2 | 1 | E2E2 | 1 | ||
| E2E3 | 9 | E2E3 | 2 | E2E3 | 4 | E2E3 | 2 | ||
| E2E4 | 2 | E2E4 | 2 | E2E4 | 7 | E2E4 | 3 | ||
| E3E3 | 119 | E3E3 | 60 | E3E3 | 50 | E3E3 | 32 | ||
| E3E4 | 80 | E3E4 | 71 | E3E4 | 73 | E3E4 | 19 | ||
| E4E4 | 10 | E4E4 | 44 | E4E4 | 11 | E4E4 | 3 | ||
| TOTAL | 226 | 180 | 146 | 60 | |||||
| C | O | N | T | R | O | L | S | ||
| 0-59years | 60-69years | 70-79years | >80 years | ||||||
| E2E2 | 0 | E2E2 | 1 | E2E2 | 0 | E2E2 | 0 | ||
| E2E3 | 10 | E2E3 | 13 | E2E3 | 16 | E2E3 | 5 | ||
| E2E4 | 2 | E2E4 | 4 | E2E4 | 7 | E2E4 | 1 | ||
| E3E3 | 60 | E3E3 | 62 | E3E3 | 59 | E3E3 | 29 | ||
| E3E4 | 28 | E3E4 | 19 | E3E4 | 15 | E3E4 | 5 | ||
| E4E4 | 3 | E4E4 | 0 | E4E4 | 2 | E4E4 | 0 | ||
| TOTAL | 103 | 44 | 99 | 40 |
This table shows that ApoE E4 is a risk factor for Alzheimer's disease
However, despite the several thousands papers on this risk factor, ApoE genotype is neither useful for the diagnostic, nor for the treatment, up to now.
Only E4/E4 patients have a genetic profile that can be taken into account by the clinician. These patients represent less than 2% of the population.
Campion has noticed a segregation of this E4/E4 genotype in some families, giving a "familial" phenotype
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