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PSP
PEP
Semantic  Dementia
SSP
  ToD
A L Z H E I M E R
0-59years 60-69years 70-79years >80 years
E2E2 0 E2E2 1 E2E2 1 E2E2 1
E2E3 9 E2E3 2 E2E3 4 E2E3 2
E2E4 2 E2E4 2 E2E4 7 E2E4 3
E3E3 119 E3E3 60 E3E3 50 E3E3 32
E3E4 80 E3E4 71 E3E4 73 E3E4 19
E4E4 10 E4E4 44 E4E4 11 E4E4 3
TOTAL 226 180 146 60
  C O N T R O L S
0-59years 60-69years 70-79years >80 years
E2E2 0 E2E2 1 E2E2 0 E2E2 0
E2E3 10 E2E3 13 E2E3 16 E2E3 5
E2E4 2 E2E4 4 E2E4 7 E2E4 1
E3E3 60 E3E3 62 E3E3 59 E3E3 29
E3E4 28 E3E4 19 E3E4 15 E3E4 5
E4E4 3 E4E4 0 E4E4 2 E4E4 0
TOTAL 103 44 99 40

This table shows that ApoE E4 is a risk factor for Alzheimer's disease

However, despite the several thousands papers on this risk factor, ApoE genotype is neither useful for the diagnostic, nor for the treatment, up to now.

Only E4/E4 patients have a genetic profile that can be taken into account by the clinician. These patients represent less than 2% of the population.

Campion has noticed a segregation of this E4/E4 genotype in some families, giving a "familial" phenotype

 

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