| Alzheimer |
| Brain diseases |
| Research |
| Tau |
| APP |
| Abeta |
| VCDN group |
 |
| ALS/PDC Guam |
| AGD |
| Bri |
| CBD |
|
DLDH |
| DM1 |
| Down S |
| GSS |
| FTD |
| FTDP-17 |
| Huntington |
| Hallenvorden |
| IBM |
| Lewy BD |
| MSA |
| NPiD c |
| Parkinson D Guadeloupe |
| Parkinson |
| Dementia Êin ParkinsonÊ |
| Pick |
| Prion |
| PSP |
| PEP |
| Semantic ÊD |
|
SSP |
| Ê ToD |
Other diseases
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Neurodegenerative disorders with gene defects
Other diseases
| Equipe VCDN | Team VCDN | Publications VCDN |
| Maladie d'Alzheimer | Alzheimer's disease index | Communication / documentation |
| Dégénérescence frontotemporale | Neurological disorders | Immunological tools |
Neurodegenerative diseases with triplet repeats expansion:
UF de Neurobiologie, Laboratoire de Biochimie et Biologie moléculaire, Hopital R.Salengro
Bd du Pr Leclerc. 59037 LILLE, France
Tél: 33320446173 Fax:33320446919
Manager: Professor B.Sablonniere (M.D, Ph.D.)
Assistants: Docteur N.Emery (Ph.D)
Docteur S.Schraen (Ph.D)
Docteur I.Vuillaume (M.D)
1.Molecular DNA tests used for diagnosis:
*Neurodegenerative diseases with triplet repeats expansion:
- Huntington Disease (HD)
- Spinocerebellar Ataxia: type I and II
(SCA1,SCA2,SCA3,SCA6,SCA7)
- Friedreich's Ataxia (GAA repeat expansion)
- Dentatorubral and pallidoluysian atrophy (DRPLA)
- Spinobulbar and Muscular Atrophy (SBMA)
*Neuromuscular Disorders:
- Spinal and muscular Atrophy (SMN gene)
- Myotonic Dystrophy (CTG repeat expansion)
- Charcot-Marie-Tooth Disease: type 1A ( PMP22 gene duplication)
- Hereditary Neuropathy with Pressure Palsies (HNPP), ( PMP22 gene deletion)
2. Western blot analysis of muscular proteins:
- Duchenne and Becker Muscular Dystrophy (dystrophin)
-Sarcoglycanopathies (adhalin and other sarcoglycans)
- Congenital Muscular Dystrophy (Mérosine)
3. Enzymatic screening:
-Enzymatic complexes of the mitochondrial respiratory chain.
(from muscular biopsies)
