Alzheimer
Brain diseases
Research
Tau
APP
Abeta
VCDN group
flag

Aging

ALS

ALS/PDC Guam
AGD
Bri
CBD
DLDH
DM1
Down S
GSS
FTD
FTDP-17
Huntington
Hallenvorden
IBM
Lewy BD
MSA
NPiD c
Parkinson D Guadeloupe
Parkinson
Dementia in Parkinson
Pick
Prion
PSP
PEP
Semantic D
SSP
ToD

Down Syndrome

Despite the fact that DS patients have early the Alzheimer type lesions in their brains, these patients do not systematically develop  an Alzheimer-type dementia.

The genetic heterogenity of these patients should push researchers to use this pathology with care, because of possible pittfalls in their interpretation.

APP  on chromosome 21 is likely to explain the amyloid plaques, since this protein is overexpressed in DS.

Tau pathology is similar to the Alzheimer one, with a characteristic triplet of pathological tau proteins.