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DLDH (dementia lacking distinctive histology)

 

General outline
Fronto temporal neurodegenerative disorder resulting from a massive neuronal loss, provoking a spongiosis, and a reaction of glial cells, namely gliosis.

Synonyms: Frontotemporal dementia, non-Alzheimer, non-Pick
Course (Evolution of the disease): see FTD
Caregiver problems: see FTD

Aetiology (Causes and risk factors)
These FTD are also named FTD non-Alzheimer, non-Pick, to emphasize that there are no accumulation of tau proteins. This is indeed quite right. However, levels of normal tau protein are dramatically decreased, suggesting that this fronto-temporal dementia is also a tauopathy (Zhukareva, V., V. Vogelsberg-Ragaglia, et al. (2001). "Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia." Ann Neurol 49(2): 165-75).

- Diagnostic procedures
See FTD for clinical and imaging approaches

- Treatment and rehabilitation
See FTD 

- Ongoing research
Research on the physiopathology of tau proteins, likely involved in the process

- Available services
-. Further reading