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Cleavage of APP and Ab production

 
Ab is a 40 to 43 amino-acid peptide
Ab deposits are in the grey matter of cortical areas
Ab 42 and 40 distribution in the aging brain
Ab 42 and 40 distribution in Alzheimer's disease
 
N-truncated Ab 42 species are the germs of amyloid
Ab clearance
 Ab neurotoxicity
Ab therapeutic approaches
The compounds that decrease Ab production
The compounds that increase Ab production
Ab antibodies

APP cleavage for the production of Ab ......BACE1 Gene location

Dysfunction of APP

 Ab 42 and 40 deposition versus pathological tau stages

Tau pathology precedes Ab deposits in sporadic  AD
  Tau is upstream the amyloid cascade 
The amyloid cascade hypothesis
12/18/2004
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