Cleavage of APP and Ab production

Ab is a 40 to 43 amino-acid peptide

Ab deposits are in the grey matter of cortical areas

Ab 42 and 40 distribution in the aging brain

Ab 42 and 40 distribution in Alzheimer's disease

N-truncated Ab 42 species are the germs of amyloid

Ab clearance

Ab neurotoxicity

Ab therapeutic approaches

The compounds that decrease Ab production

The compounds that increase Ab production

Ab antibodies

APP cleavage for the production of Ab ......BACE1 Gene location

Dysfunction of APP

Ab 42 and 40 deposition versus pathological tau stages

Tau pathology precedes Ab deposits in sporadic  AD

Tau is upstream the amyloid cascade

The amyloid cascade hypothesis