NEUROTOXICITY OF INTRACELLULAR Ab

Neurotoxicity of extracellular Abeta deposits

1) killing neurons from the inside

This peptide aggregates inside the cell body of nerve cells, and could induce neurodegeneration very early, before it is found in the extracellular domain

2) "beta-Amyloid inhibits integrated mitochondrial respiration and key enzyme activities." J Neurochem. 80(1): 91-100, 2002.

3) MICKI mouse demonstrates the neurotoxicity of intracellular deposits (Model with Intra Cellular abeta deposition, KnockIn for ps1 )

Transgenic mice with APP mutations (Swedish, London) knock-in for PS1 (with two mutations) develop huge intracellular Abeta deposits and neuronal cell death in the hippocampal area (Casas et al, 2004).