Ab is overproduced in familial Alzheimer's disease. This fact suggests that Ab is a non-desirable, possibly toxic, compound.

Among all the compounds, drugs, foods that we absorb on earth, one can ask if there are some of them that decrease Ab production. Such products are likely to slow down Alzheimer's disease.

We report here papers that describe some of them.

Those that decrease Abeta via an activation of clearance

Those that act via another mechanisms:

Anti-oxidants:

1) curcumin

J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7.

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.

2) epigallocatechin gallate

J Neurosci. 2005 Sep 21;25(38):8807-14.

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, Hardy J, Town T, Tan J.