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Ab overproduction

Ab is overproduced in familial Alzheimer's disease. This fact suggests that Ab is a non-desirable, possibly toxic, compound.

Among all the compounds, drugs, foods that we absorb on earth, one can ask if there are some of them that increase Ab production. Such products are likely to anticipate or to accelerate Alzheimer's disease.

We report here papers that describe some of them.

PubMed - 15834426
Source
Kukar T, Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production., Nat Med  2005 Apr;(): PubMed Abstract
Abstract
Increased Abeta42 production has been linked to the development of Alzheimer disease. We now identify a number of compounds that raise Abeta42. Among the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celecoxib, a COX-2-selective NSAID. Many......

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production., J Neurosci 2005 Oct;25(41):9367-77. Lesné S et al.

Nutr Metab (Lond). 2005 Oct 17;2(1):28
A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease. Van der Auwera I, Wera S, Van Leuven F, Henderson ST.



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