• 
• APP is a transmembrane protein.
• APP is cleaved inside the membrane and the gamma stub released
• This type of cleavage was unknown
• In fact, it is present in a group of proteins
  • Notch
    Erb-B4
    APP, APLP1, APLP2
    N-Cad
    LRP
    Syn-3
  • p75NTR (neurotrophin receptor)
  • ApoER2
  • EphrinB
  • neuroregulin NRG2
• In general, the cleavage products (ICD for Incellular Domain) have a specific functional role.

Coolen et al, 2006 ;