APP metabolism and function

Primary structure, sequence and functional regions

Cartoon on the structure

APP splicing

Mutations

Cascade hypothesis

APP & cholinergy

Links between APP and neurodegeneration

Abeta map

APP Carboxy terminal fragments,  a and b stubs ...........Sequence and functional regions

All data on APP via Swiss-Prot

Cleavage of APP, production of APP-CTFs and Abeta

alpha secretase cleavage

beta secretase (BACE, ...)

gamma secretase     and       PS1

sa-APP,a possible neuroprotectant

RIP: regulated intramembrane proteolysis

APP- Tau interaction

The APP/APLP family

Other molecular aspects