APP and Presenilins, key players of Alzheimer's disease
Molecular structure of APP and Abeta peptide. Description of some functionnal regions.
- APP (amyloid protein precursor) gene is on chromosome 21
- Pathological mutations in the Abeta coding sequence of APP gene provoke familial Alzheimer's disease (see figure)
- Several regions of APP have trophic properties
- APP is a transmembrane protein, which is normally clived by enzymes, named secretases.
- Secretases are responsible for the production of Abeta peptides, of different lenghts (39 to 43 aminoacids)
- Secretases release sAPP, the extracellular part of APP, which is likely to play important physiological roles, including trophic activities
- Abeta 40 and 42 are the main components of amyloid plaques
- Abeta 42 is more directly linked to AD than Abeta 40
| Alzheimer |
 |
| Research |
| Tau |
| APP |
| Abeta |
| ApoE |
| catenin |
| NSE |
| Parkin |
| Pin1 |
| Presenilins, |
| Proteasome |
| Synuclein |
| Ubiquitin |
