Alzheimer
Brain diseases
Research
Tau
APP
Abeta
VCDN group
flag

Aging

ALS

ALS/PDC Guam
AGD
Bri
CBD
DLDH
DM1
Down S
GSS
FTD
FTDP-17
Huntington
Hallenvorden
IBM
Lewy BD
MSA
NPiD c
Parkinson D Guadeloupe
Parkinson
Dementia  in Parkinson 
Pick
Prion
PSP
PEP
Semantic  D
SSP
  ToD
  • APP is a transmembrane protein.
  • APP is cleaved inside the membrane and the gamma stub released
  • This type of cleavage was unknown
  • In fact, it is present in a group of proteins
    • Notch
      Erb-B4
      APP
      N-Cad
      LRP
      Syn-3 p75NTR
  • In general, the cleavage products have a specific functional role
Alzheimer
Flag
Research
Tau
APP
Ab
 
ApoE
 
catenin
 
NSE
 
Parkin 
Pin1 
Presenilins,
Proteasome
Synuclein 
 
 
Ubiquitin
 
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